Bees Therapeutics address the field of anti-immune check-point immunotherapies
using a breakthrough immune response potentiating technology
Blue Bees Therapeutics technology
consists of protein complexes combining an L1 ligand of a receptor selectively expressed
on the surface of immune cells, with an L2 ligand of Heparan Sulfate
Proteoglycans (HSPGs). HSPGs represent a family of molecules ubiquitously
expressed by most cells. They often act as co-receptors promoting cell
signaling and can thus modify receptor-mediated activation (Xie et al., 2019,
Cell Signal., 54:115-121). Our L1-L2 complexes take advantage of these
Potentiation of immune cell activation occurs
through binding of L2 to the HSPG co-receptor subsequent to binding of L1 to
its specific receptor. It leads to expansion of large populations of immune
cells in vivo, in particular
dendritic cells, which contribute to anti-tumor immune response. In addition,
when coupled to an Ag, such domains can boost the specific immune response in vitro and in vivo and improve tumor control (Knittel et al., 2016, Vaccine, 34(27):3093-3101).
Blue Bees Therapeutics technology allows to produce a variety of first-in
class anti-immune check-point immunotherapies specific to existing or new immune
Immune cells express a wide array of receptors that
might contribute to immune cell activation and thus might behave as immune
check-points. However, L1 antibody ligands that bind to these receptors do not
always trigger a sufficient signaling for an appropriate activation. This limitation is
waived by associating the L1 antibody ligands with the L2 HPSG ligand that
Blue Bees Therapeutics technology allows to easily
create a variety of L1-L2 complexes against a wide array of receptors. These L1-L2
complexes can be used to screen receptor-mediated activation of different immune
cell types as well as the impact on tumor control. This selection process
leads to the definition of new first-in class immune checkpoints immunotherapies
specific to existing or new immune check-points.
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